Evolutionary Perspective of Fungal Pathogenic Genes

Vinod Cingeetham, Srinivas Bandaru, Sujata Dhar, Ranganath Gudimella, Sivaramaiah Nallapeta, Krishna Mohan Medicherla


Fungal pathogenesis has been vastly investigated in recent years and the phylogenic studies of fungal genome reveal that unique genes are responsible for pathogenesis. It has been found that the pathogenesis is caused by genes responsible for DNA repair, vegetative growth and sporulation. In the recent past, studies on filamentous pathogenic fungi playing an important role in establishing a pathogenic relationship with the host was well described.

Full Text:



Cao Y, Zhu X, Jiao R, Xia Y. The Magas1 gene is involved in pathogenesis by affecting penetration in Metarhizium acridum. J Microbiol Biotechnol. 2012; 22(7):889-93.

Ascioglu S, Rex JH, de Pauw B, Bennett JE, Bille J, Crokaert F, Denning DW, Donnelly JP, Edwards JE, Erjavec Z, Fiere D, Lortholary O, Maertens J, Meis JF, Patterson TF, Ritter J, Selleslag D, Shah PM, Stevens DA, Walsh TJ; Invasive Fungal Infections Cooperative Group of the European Organization for Research and Treatment of Cancer; Mycoses Study Group of the National Institute of Allergy and Infectious Diseases. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis. 2002;34(1):7-14

Gudimella R, Nallapeta S, Varadwaj P, Suravajhala P. Fungome: Annotating proteins implicated in fungal pathogenesis. Bioinformation. 2010; 5(5):202-7.

Gary P, Coleman C and Sullivan D. Comparative Genomics and the Evolution of Pathogenicity in Human Pathogenic Fungi. Euk. Cell. 2011; 34-42

Tierney L, Linde J, Müller S, Brunke S, Molina JC, Hube B, Schöck U, Guthke R, Kuchler K. An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells. Front Microbiol. 2012;3:85

Magditch DA, Liu T-B, Xue C, Idnurm A (2012) DNA Mutations Mediate Microevolution between Host-Adapted Forms of the Pathogenic Fungus Cryptococcus neoformans. PLoS Pathog 8(10): e1002936.

Schafer W. Molecular Mechanisms of Fungal Pathogenesis. (1994) Ann. Rev. Phytopathol. 32: 461-77