Treatment Strategies for COVID 19: New Insights from Comparative Genome Analysis, Pathophysiology, Host-Virus Interaction and Immune Response

Athira M Menon, Tushar Ivanti, Ankita Sharma, Sunil Dutta Purohit, Joginder Singh Saklani, Abhishek Kumar, Narendra Kumar Sharma, Amit Sharma, Tikam Chand Dakal


The recent outbreak of Coronavirus (SARS-CoV-2, earlier known as 2019-nCoV) in Wuhan City, China and its subsequent spread in other countries have posed a big threat to human health. The speed with which this virus has spread across the globe was unimaginably fast that within a span of 2 months, more than 100 countries became victims of its vicious trap. As of today, there is no potent therapeutic regime available in any form (drug, vaccine or other) for effective treatment of COVID19. In this review, we have presented therapeutic solution of COVID 19 based of understanding drawn from comparative genome analysis, pathophysiology, host-virus interaction and immune response. Herein, we have presented the genomic and structural organization of the virus have been studied which pose an immense resemblance with the previously reported coronaviruses. The SARS-CoV-2 is highly contagious and its infectivity is unimaginably high as compared to all previously known coronaviruses such as SARS-CoV-1, MERS-CoV, CoV-NL63, CoV-229E, CoV-HUK1, CoV-OC43 and others. Further, we aimed to describe the complex etiology, deregulated immune response and other pathophysiological outcomes of SARS-CoV-2 infection so as to define their unimaginable high infectivity and transmission properties. In addition, we discuss about the current status of screening tests, drugs, reprofiled drugs, vaccines and other therapies that are under different stages of development. The biorhythm and host response on infection have also been studied which can sanguinely open the door for treatment of the disease. No vaccination or drug candidate has been identified yet but the use of the repurposed drug of its ancestors and other related causal organisms have shown promising results and recovery of the patients.


Coronavirus, Genome Structure, Life cycle of SARS-CoV-2, Spike Protein, Therapeutics

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