ATPase Domain of Heat Shock protein 70—isoform 2—(Hsp70-2) and their role in activating the adaptive immune response: An in silico approach

Jose Gregorio Marchan

Abstract


A lot of molecules play fundamental roles in neoplasic processes and cancer. Heat shock proteins may enhance this severe pathology and favor the protumoral milieu. However, a look at the literature tells us that these molecules intervene in both to promote or attack cancer cells. In the case of breast cancer is known that Hsp70 (isoform 2) improve this establishment and progression in the patient, and is possible that the ATPase domain of Hsp70-2 favors this disease. Thus, is relevant to know if this molecular region has immunogenic activity as well as which epitopes are essential to stimulate immune cells, and whether could induce the attack of the tumor mass. In this aim, the immunogenicity of ATPase domain of Hsp70-2 was studied in silico. The results suggest that the majority of the molecule had immunogenic epitopes that boosts the immune response through activation of B cells and T cells. However, in vitro synthesis and in vivo experimental studies to evaluate the efficacy of this therapeutic candidate are required to ensure efficacy and safety in people. 


Keywords


Hsp70-2; ATPasa Domain;Adaptive immune response, in silico; Cancer

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