Exploring the pre-erythrocytic stage of the malaria parasite for possible target proteins to develop an effective vaccine and looking into available preventive measures against malaria:Can SPECT & SPECT2 act as potential targets for an effective vaccine?

Manas Sanjay Joshi, Shama Najir-Ahmed Mujawar

Abstract


Malaria is most commonly found in tropical and sub-tropical countries of Africa. In a year, 3.2 billion people are at risk of getting malaria of which infection occurs in over 200 million of which one million results in death; hence it is one of the most infectious parasite diseases. 90% of the deaths occur in south of Saharan desert and most of the cases are of children under the age of five. In the year 2012, malaria caused estimated total deaths of 627,000.  In the year 2013, malaria caused estimated total deaths of 500,000. 40% of total malaria cases in the world are from Nigeria and the Democratic Republic of Congo (Statistics provided by WHO). These stats strongly suggest the need of a preventive malaria vaccine. Here we analyze the malaria parasite cycle, specifically pre-erythrocytic stage, and present some possible target proteins. We also look at the current options for prevention of malaria.


Keywords


SPECT;SPECT2;Pre-erythrocytic cycle of the malaria parasite

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References


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