Modelling and Computational Sequence Analysis of a Bacteriocin Isolated from Bacillus licheniformis strain BTHT8
Bacteriocins are ribosomally synthesized antimicrobial peptides displaying different mode of action. Non pathogenic Bacillus licheniformis are usually associated with plants and produce several bacteriocins. This work looks at drug designing strategies using protein modelling and bioinformatics tools. In this study computational modelling and docking studies were carried out using the 13 amino acid sequence of a previously characterized thermostable bacteriocin, BL8 produced by B. licheniformis strain BTHT8. These analyses enabled the understanding of the structure of BL8 protein domain, which was noted to belong to alpha + beta protein fold family. In addition, the docking study predicted that BL8 has properties of angiotensin-converting enzyme (ACE) inhibitor.
Bacteriocin; Bacillus licheniformis; Docking; ACE inhibitor